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NOVEL AMPLICON IN THE 20Q13 REGION OF HUMAN CHROMOSOME 20 AND USES THEREOF

机译:人类20号染色体2013年第20季度的新型扩增子及其用途

摘要

This invention pertains to the field of cancer genetics and cytogenetics. Inparticular, this invention pertains to the identification of a novel ampliconon human chromosome 20 which is associated with cancer. More particularly thisinvention pertains to the identification of a novel "amplicon" or genomicnucleic acid in a region of amplification at about 20q13.2 which has beenassociated with a variety of cancers, particularly breast cancer. The novelamplicon of the invention can be used as a probe specific for this region of20q13.2 as well as for the diagnosis and prognosis of various cancers. Alsoprovided are kits for screening for the presence and copy number of the novelamplicon of the invention in a sample containing human nucleic acid.
机译:本发明涉及癌症遗传学和细胞遗传学领域。在特别地,本发明涉及新型扩增子的鉴定在与癌症有关的人类20号染色体上。更特别的是本发明涉及新型“扩增子”或基因组的鉴定大约20q13.2处的扩增区域中的核酸与多种癌症,尤其是乳腺癌有关。小说本发明的扩增子可用作特异性针对该区域的探针。20q13.2以及用于各种癌症的诊断和预后。也提供的试剂盒用于筛选小说的存在和拷贝数含有人核酸的样品中的本发明的扩增子。

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