REVERSIBLE BORONATE COMPLEXES OF 1,2-CIS-DIOL CYCLIC-PEPTIDES

摘要

Reversible borate or boronate complexes of 1,2-cis-diol cyclic-peptides andtheir use as a means for purification, isolation, stabilization and/or watersolubilization of their respective parent 1,2-cis-diol cyclic-peptide isdescribed. A method for forming the boronate adducts is also described. Themethod is particularly useful for forming boronate adducts of hydrophobicEchinocandin compounds to increase their water solubility. Pharmaceuticalformulations and treatments based on the reversible borate or boronatecomplexes of active 1,2-cis-diol cyclic-peptides (e.g., Echinocandinantifungal compounds) are also described.