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Cyclic adenosine diphosphate ribose analogues for modulating t cell activity
Cyclic adenosine diphosphate ribose analogues for modulating t cell activity
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机译:环状腺苷二磷酸核糖类似物,用于调节t细胞活性
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摘要
Compounds capable of antagonising a sustained cADPR-mediated rise in intracellular Ca2+ levels in a T cell, said rise being in response to stimulation of the T cell receptor/CD3 complex of the T cell, methods for identifying the same and their use in modulating T cell activity are described. The preferred compounds are cyclic adenosine diphosphate ribose analogues.
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