CYCLIC ADENOSINE DIPHOSPHATE RIBOSE ANALOGUES FOR MODULATING T CELL ACTIVITY

摘要

Compounds capable of antagonising a sustained cADPR-mediated rise in intracellular Ca2+ levels in a T cell, said rise being in response to stimulation of the T cell receptor/CD3 complex of the T cell, methods for identifying the same and their use in modulating T cell activity are described. The preferred compounds are cyclic adenosine diphosphate ribose analogues.