5-membered heterocycles for the treatment of human diseases involving modulatorsof selectins

摘要

Compounds of Formula (1) (where at least one of R1, R2 or R3 contains calcium binding moiety e.g. CO2H etc.) are disclosed. Where R1 is typically a moiety containing a terminal carboxylic acid group such as cinnamic acid or phenoxy acetic acid, R2 is typically a hydrophobic moiety such as functionalized alkyl chain or a functionalized aryl group, and R3 is typically a functionalized aryl group, are within the scope of this invention. These compounds exhibit inhibitory activity against P-, L- and E-selectin and are indicated in the treatment of human diseases involving P-, L- and E-selectin.