Synthetic and therapeutic methods for the alpha and beta domains of metallothionein

摘要

The present invention relates to the alpha and beta domains of metallothionein and analogs thereof, their synthesis, and therapeutic applications of them. Purified metal-free and metal containing alpha and beta domains of metallothionein are provided. A high yield method of synthesis and purification is also provided for the metal-free and metal containing alpha and beta domains of metallothionein. Finally, therapeutic methods are provided that use the alpha and beta domains of metallothionein to transport selected metals to specific tissues or to sequester metals from these tissues in order to treat conditions in those tissues that are ameliorated by the addition or sequestration of these metals.