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Therapeutic and diagnostic applications of prostatic acid phosphatase in prostate cancer
Therapeutic and diagnostic applications of prostatic acid phosphatase in prostate cancer
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机译:前列腺酸性磷酸酶在前列腺癌中的治疗和诊断应用
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摘要
Presented is a therapeutic method to treat prostate carcinomas in mammals comprising the administration of cellular PAcP protein. Also presented is a method to diagnose androgen-insensitive prostate carcinomas by determining the expression level of cellular PAcP in the prostate carcinomas, a decrease in expression being indicative of androgen-insensitivity. A promoter region that is specifically expressed in prostate tissue is presented, as is a xenograft animal model that mimics human prostate carcinomas in the expression of cellular PAcP.
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