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One pot synthesis of 5'-hydroxy phosphorylated nucleoside derivatives, and compounds formed thereby
One pot synthesis of 5'-hydroxy phosphorylated nucleoside derivatives, and compounds formed thereby
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机译:一锅合成5'-羟基磷酸化核苷衍生物及其形成的化合物
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摘要
A method for the preparation of 5'-hydroxy phosphorylated nucleoside derivatives in a single reaction vessel is provided. The method includes contacting phosphorous oxychloride with a halophenyl moiety followed by contacting the resulting halophenylphosphorodichloridate with a carboxy-protected amino acid and finally contacting the resulting halophenyl carboxy-protected amino acid phosphorochloridate with a nucleoside.
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