A method of altering the properties of a membrane-associated protein by substitution of the transmembrane domain

摘要

The invention relates to methods of altering the properties of membrane-associated proteins, by substituting the transmembrane region. In this way, for example, the level of expression of the protein can be altered as well as properties of the protein itself, such as the relative response of the membrane-associated protein to cell surface-associated antigen versus antigen in solution and the sensitivity of intracellular signalling mediated by the membrane-associated protein.