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Method for alpha metalation of a derivative which is heterocyclic, monocyclic orpolycyclic and possesses at least one 5-atom heterocycle and is unsaturated or aromatic
Method for alpha metalation of a derivative which is heterocyclic, monocyclic orpolycyclic and possesses at least one 5-atom heterocycle and is unsaturated or aromatic
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机译:杂环,单环或多环并具有至少一个5-原子杂环且为不饱和或芳香族的衍生物的α金属化方法
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摘要
The invention relates to a method for alpha metalation of a derivative which is heterocyclic, monocyclic or polycyclic and possesses at least one 5-atom heterocycle and is unsaturated or aromatic or substituted. The invention is characterized in that said derivative is reacted with an efficacious amount of at least one alkaline metal in the presence of a compound of formula (I): RCI, wherein R represents a hydrocarbon radical having 1-20 carbon atoms and which can be a saturated or unsaturated, linear or branched acyclic aliphatic radical; a saturated, unsaturated, monocyclic or polycyclic cycloaliphatic radical; a saturated or unsaturated, linear or branched aliphatic radical carrying at cyclic substituent.
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