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Kit of drug-containing preparation to be prepared before using and resolvent therefor

机译:使用前需要准备的含药制剂及其解决方法

摘要

A kit of a drug-containing preparation to be prepared before using which has as constituents thereof a drug and fine granular preparation having an average grain size of 100 nm or less; and a kit to be prepared before using in which no insoluble foreign matter is formed and the presence of any insoluble foreign matter can be observed with the naked eye, thus achieving a high safety, owing to a resolvent for a drug comprising a fine granular preparation having an average grain size of 100 nm or less. Namely, a drug-containing preparation prepared from the above kit is safely applicable to injections, etc., since no insoluble foreign matter is formed therein. Moreover, the drug-containing preparation has a low turbidity so that the presence of any insoluble foreign matter therein can be easily confirmed with the naked eye, thereby achieving an improved stability. The resolvent and the kit are applicable to drugs which show only a poor storage stability in the conventional fine granular preparations and those which can be hardly processed into fine granular preparations. Moreover, drugs can be administered at physiological pH value thereby.
机译:使用前要制备的含药物制剂的药盒,其成分为平均粒径为100nm以下的药物和细粒制剂。以及在使用前制备的试剂盒,其中不形成不溶性异物,并且可以用肉眼观察到任何不溶性异物的存在,因此由于包含细粒制剂的药物的溶解剂而实现了高安全性具有100nm或更小的平均晶粒尺寸。即,由上述试剂盒制备的含药物制剂可安全地用于注射剂等,因为其中不会形成不溶性异物。此外,含药物制剂的浊度低,因此可以用肉眼容易地确认其中存在任何不溶性异物,从而提高了稳定性。该溶解剂和试剂盒适用于在常规的细颗粒制剂中仅显示出较差的储存稳定性并且难以加工成细颗粒制剂的那些药物。此外,由此可以在生理pH值下施用药物。

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