INHIBITION OF NF-λB MEDIATED TISSUE INJURY USING DITHIOCARBAMATE DERIVATIVES

摘要

Methods for treating inflammatory responses in a mammalian patient based on administration of cyclic dithiocarbamate (DTC) and thiuramsulfide (TS) derivatives are disclosed. Antiinflammatory effective amounts of cyclic DTC or TS derivatives are administered to a mammalian patient to treat ischemia/reperfusion injury, systemic inflammatory response syndrome (SIRS) and oxidative stress-related conditions. Useful compounds include DTCs and TSs having one or more structural modifications selected from substituent(s) in a bridge portion of a ring member of the compound, heteroatom(s) within the bridge portion, carbonyl function(s), and/or dehydrogenation to yield one or two double bonds within the compound. Methods of treatment specifically inhibit NF-λB activity and oxidative stress effects while not substantially inhibiting beneficial pathways of inflammation.