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GENE TRANSFER OF HUMAN E2F-1 TO INHIBIT VASCULAR SMOOTH MUSCLE CELL GROWTH
GENE TRANSFER OF HUMAN E2F-1 TO INHIBIT VASCULAR SMOOTH MUSCLE CELL GROWTH
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机译:人类E2F-1的基因转移抑制血管平滑肌细胞的生长
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摘要
Methods for induction of E2F-1 related vascular smooth muscle cell (VSMC) death to limit vascular stenosis or restenosis, to regress atherosclerotic plaque and to prevent atherogenesis are disclosed. Also disclosed is an adenovirus vector containing the E2F-1 gene, and a method of transferring the gene to a vessel or graft. A method of limiting cell proliferation and/or reducing cell numbers includes transferring the E2F-1 gene into VSMC to achieve overexpression of E2F-1 gene product, which drives vascular cells into S-phase and thereby causes their subsequent death.
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