EFFECTS OF GDNF AND NGF ON SODIUM CHANNELS IN DRG NEURONS

摘要

The present invention provides a new means for altering or modulating inappropriate electrical activity which may be involved in pain syndromes. The present invention includes methods to treat pain or hyperexcitability phenomena by altering or modulating the sodium channel expression or activity. The present invention also includes methods of identifying agents which modulate TTX-R Na+ current through channels, particularly NaN channels, by altering or modulating the level or activity of the channel or by altering or modulating the expression or activity of a neurotrophin.