METHODS AND COMPOSITIONS FOR IDENTIFYING EFFECTORS OF THE FORMYL PEPTIDE RECEPTOR LIKE-1 (FPRL-1) RECEPTOR

摘要

The present invention makes available rapid, effective assays for screening and identifying pharmaceutically effective compounds that specifically interact with and modulate the activity of a cellular receptor or ion channel. The subject assays enable rapid screening of large numbers of polypeptides in a library to identify those polypeptides which induce or antagonize receptor bioactivity. The subject assays are particularly amenable for identifying agonists and antagonists for orphan receptors. In particular the present invention makes available ligand agonists of human formyl peptide receptor like-1 (FPRL-1) receptors. These ligand agonists are used in the assays of the invention to identify modulators of FPRL-1 receptor.