CANCER RELATED TO HUMAN CHROMOSOME 16Q TUMOR SUPPRESSOR GENE

摘要

A polynucleotide comprising all, or a variant, or part thereof, of human chromosome 16q tumour suppressor gene or all, or a variant, or a part of an mRNA or cDNA derived from the tumour suppressor gene wherein the tumour suppressor gene contains at least part of the nucleotide sequences shown in any one of Figures 4, 5, 6, 7, 8, 9, 15, Z1, 23 or 31. A method of diagnosing cancer in a patient comprising the steps of (i) obtaining a sample containing nucleic acid from the patient; and (ii) contacting the said nucleic acid with a nucleic acid which hybridises selectively to the human chromosome 16q tumour suppressor gene, or a mutant allele thereof, or a nucleic acid which hybridises selectively to human chromosome 16q tumour suppressor gene cDNA, or a mutant ellele thereof, or their complement. A method of treating a proliferative disease comprising the step of administering to the patient a nucleic acid which encodes the human chromosome 16q tumour suppressor polypeptide or a functional variant or portion or fusion thereof.