USE OF THIAZOLIDINEDIONES TO AMELIORATE THE ADVERSE CONSEQUENCES OF MYOCARDIAL ISCHEMIA ON MYOCARDIAL FUNCTION AND METABOLISM

摘要

The present invention provides methods and compositions for (a) enhancing resistance to myocardial ischemia associated dysfunction, including contraction (systolic), relaxation (diastolic) and metabolic dysfunction, comprising the step of administering to a human determined to be susceptible to myocardial ischemia an effective amount of an insulin sensitizer; and (b) reducing hypertension comprising the step of administering to a hypertensive human determined to have normal insulin sensitivity, an effective amount of an insulin sensitizer. In a particular embodiment, the sensitizer comprises a thiazolidinedione compound, such as triglitazone.