BRG1 IS A TUMOR SUPPRESSOR THAT IS MUTATED IN PROSTATE AND OTHER CANCER TYPES

摘要

The present invention relates to the relation of the BRG1 gene (also called SNF2α) to human cancers and its use in the diagnosis and prognosis of human cancer. The invention also relates to the therapy of human cancers which have a mutation in the BRG1 gene, including gene therapy, protein replacement therapy and protein mimetics. Finally, the invention relates to the screening of drugs for cancer therapy.