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Chlorophyll and bacteriochlorophyll derivatives, their preparation and pharmaceutical compositions comprising them
Chlorophyll and bacteriochlorophyll derivatives, their preparation and pharmaceutical compositions comprising them
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机译:叶绿素和细菌叶绿素衍生物,其制备以及包含它们的药物组合物
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摘要
Conjugates of chlorophyll (Chl) and bacteriochlorophyll (Bchl) derivatives with amino acids, peptides and proteins are provided by the invention.The amino acid, peptide or protein residue is linked to the 17-propionic acid group of a Chl or Bchl residue directly or through a chain.The conjugates are for use as photosensitizers in photodynamic therapy and in diagnostics of tumors. Conjugation with cell-specific ligands, such as hormones, growth factors or tumor-specific antibodies, will target the Chl or Bchl moiety to the tumor site. Thus, conjugates with melanocyte stimulating hormones are suitable for photodynamic therapy of melanoma tumors.
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