METHODS AND COMPOSITIONS FOR INDUCING PHASE SEPARATION OF EPITHELIAL LIPID BILAYERS

摘要

A method for inducing phase separation of the epithelial multilayered lipid bilayers within the intercellular spaces of the stratum corneum in a host in need of the topical administration of a physiologically active substance delivered percutaneously or transdermally which comprises applying to the epithelium of the host, an effective amount of one or more intercellular phase-separating agents, as well as a topical composition useful therefor.