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BISPECIFIC ANTIBODIES FOR RETARGETING ANTICANCER CYTOTOXIC LYMPHOCYTES AND HYBRIOMAS AND MONOCLONAL ANTIBODIES THEREFORE
BISPECIFIC ANTIBODIES FOR RETARGETING ANTICANCER CYTOTOXIC LYMPHOCYTES AND HYBRIOMAS AND MONOCLONAL ANTIBODIES THEREFORE
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机译:重定位抗癌药细胞和血淋巴瘤的双特异性抗体及其因此的单克隆抗体
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摘要
A bispecific antibody has binding specificity for a marker common to all prostate cells on one arm of the antibody, and binding specificity for T cell marker CD3 on the other antibody arm. The combined specificities bring together a tumor cell and a T effector cell, whose specificity is reprogrammed to kill the tumor cell. In vitro studies showed that the bispecific antibody achieves a much greater level of cytotoxicity than either individual antibody alone.
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