Mechanism oriented inhibitors of dipeptidyl peptidase I

摘要

The present invention relates to new compounds which act as specific inhibitors of the cysteine protease dipeptidyl peptidase I (DP I). These compounds are represented by the general formula AB-NHO-Bz, in which A is an N-terminally unprotected amino acid other than proline and hydroxyproline, which is in peptide bond with B, B is an amino acid other than proline, hydroxyproline or alanine and NHO is a hydroxylamine grouping represents which is present in the amide bond with B and in the ester bond with Bz, where Bz is a benzoyl radical which is unsubstituted or substituted in the ortho, meta and / or para position.