THYMOL DERIVATIVES WITH ANTICANCER ACTIVITY AND AN ANTICANCER DRUG COMPRISING THEREOF

摘要

PURPOSE: Provided is an anticancer drug including thymol derivative of formula 1 and effective ingredient of base, ester pharmacological. CONSTITUTION: Thymol derivatives of formula 1 is provided, wherein R1 represents hydroxy, methyl and -OR6(R6 is benzyl, 4-nitrobenzyl, 4-methylbenzyl, 4-toluensulfonyl and 4-methoxybenzyl): R2 represents acetyl, isobutyl, palmitoyl, benzoyl, 4-nitrobenzoyl, 4-methylbenzoyl, phenylacetyl, 4-nitrophenylacetyl, 4-fluorophenylacetyl, 4-methoxyphenylacetyl, methanesulfonyl, 4-methoxybenzenesulfonyl, 4-nitrobenzenesulfonyl, 4-fluorobenzenesulfonyl, alpha-toluenesulfonyl, 2-nitro-alpha-toluenesulfonyl,p-toluenesulfonyl: R3 represents epoxy, diol and olefin: R5 represents hydroxy and methyl or hydrogen.