The organophosphate indazoles derivatives and their use as Drugs with anticancer activity.

摘要

Organophosphorus Compounds, particularly of indazoles Derivatives, to compositions containing them, and their use as Drugs to treat cancers.Claim 1: a product of the General formula (1), in which: W represents a group selected from a Covalent Bond or a Covalent Bond; X represents a Group c = o, - - The NRA NRA -, - C = o,- (CH2) n -, - ch = CH - - - - - CSC, NRA, S, o, - - So, SO2, co, COO in which ra represents H or an alkyl group C1 - 4 may eventually form a cycle with R1, in which n = 0, 1, 2, 3, 4, 5, 67, 8, 9, 10, 11 or 12; r1 represents H (except when x = - SO2 -, - So -), alkyl, cycloalkyl, aryl, heteroaryl; in which R1 can be eventually replaced; R and R2, identical or different,Represent H or a selected Group among the radical alkyl, cycloalkyl, aryl, heteroaryl, heterocicloalquilo, Hydroxy, alkoxy and ariloxi,In which R and R2 are eventually replaced; and represents a Covalent Bond or a radical selected from: - The NRA - or - C = c = o, - - or -, - C = o) - (CH2) - SO2 -, N -,In which ra is selected from the group consisting of H, alkyl c1-4 alkyl, and R3 c1-4 joined to form a cycle; R3 is selected from the group consisting of H and (except where it is - - or - C = o,- SO2 -, or cycloalkyl) alkyl, aryl and heteroaryl; R3, R4 can be eventually replaced; R6 and R7, identical or different, Can independently Select between: H, halogenC1-4 alkyl, cyano, c1-4 alkoxy, RC (RB) - n, - n or - C = N - (RB) RC, RC (RB) - CO, in which RB and RC are selected independently from h, c1-4 alkyl,Cycloalkyl and C3 - 6; with the exception of the remains of Group of formula (2).