PROCESS OF OPTICALLY ACTIVE 2-HALO-1-(SUBSTITUTED PHENYL)ETHANOL AND OPTICALLY ACTIVE SUBSTITUTED STYRENE OXIDE, AND METHOD OF PROMOTING THE OPTICAL PURITY OF PRODUCTION OF OPTICALLY ACTIVE 2-HALO-1-(SUBSTITUTED PHENYL)ETHANOL PRODUCED BY THE PROCESS

摘要

The present invention describes the preparation of optically active 2-halo-1- (substituted phenyl) ethanol of compound 1a or optically active styrene oxide of compound 1b. Reacting Compound 2 with phthalic anhydride to obtain a compound of Compound 3, optically resolving the obtained compound using optically active organic amine as a resolving agent, and hydrolyzing or hydrolyzing the optically decomposed compound 1a or 1b, Lt; RTI ID = 0.0 alcoholysis. / RTI The reaction scheme is as follows:;[Reaction Scheme 1];Wherein X is a halogen atom and Y is a hydrogen atom, a halogen atom, a C ₁ -C ₆ alkyl group, a C ₁ -C ₆ alkoxy group, a C ₁ -C ₆ haloalkyl group or a C ₁ -C ₆ haloalkoxy group Z is a hydrogen atom, a halogen atom or a C ₁ -C ₆ alkyl group, n is 0 or an integer of 1 to 3, and m is 0 or an integer of 1 to 2.;The obtained optically active compound is useful as an intermediate in medicine.