STRAIN OF VIRUS DISTEMPER CANIS 'VLADIMIR' FOR PREPARING VACCINE AGAINST CARNIVOROUS PLAGUE AND VACCINE 'VLADIVAK' AGAINST VIRAL CARNIVOROUS DISEASES BASED ON SAID

摘要

FIELD: veterinary science. SUBSTANCE: invention relates to producing agents used for specific prophylaxis and treatment of plague, parvoviral enteritis, adenoviral infection and infectious hepatitis in carnivorous animals. The novel attenuated strain Virus distemper canis VGNKI N "Vladimir 18-DEP" is used for preparing vaccine against carnivorous plague and mixed vaccines against carnivorous diseases. Vaccine "Vladivak" against carnivorous plague has cultural viral suspension of the strain Virus distemper canis VGNKI N "Vladimir 18-DEP" at titer of infectious activity 2.5-4.0 lg TCD₅₀/ml and any known stabilizing agent. Mixed vaccine "Vladivak-2" against plague and parvoviral enteritis in carnivorous animals has cultural viral suspension of the strain Virus distemper canis VGNKI N "18-DEP" at titer of infectious activity 2.5-4.0 lg TCD₅₀/ml, cultural viral suspension of attenuated strain Canine parvovirus "Riel" at titer of infectious activity 5 log TCD₅₀/ml, not less, and any known stabilizing agent. Mixed vaccine "Vladivak-3" against plague, parvoviral enteritis, adenoviral infection and infectious hepatitis in carnivorous animals has cultural viral suspension of the strain Virus distemper canis VGNKI N "Vladimir 18-DEP" at titer of infectious activity 2.5-4.0 TCD₅₀/ml, cultural viral suspension of attenuated strain Canine parvovirus "Riel" at titer of infectious activity 5log₂, not less, cultural viral suspension of the strain Hepatitis adenovirus "Adel" at titer of infectious activity 2log₂, not less, and any known stabilizing agent. EFFECT: enhanced immunogenic activity, broadened spectrum of vaccines based on carnivorous plague virus strain, prolonged and safety immunity against viral diseases caused by different pathogen associations. 5 cl, 3 ex