TETRALONE OR BENZOPYRANONE DERIVATIVES, METHOD OF THEIR SYNTHESIS AND DRUG

摘要

FIELD: organic chemistry, chemical technology, pharmacy. SUBSTANCE: invention describes the novel tetralone or benzopyranone derivatives and method of their synthesis that can be used as therapeutic drug for prophylaxis and treatment of patients with hormone-depending diseases. New tetralone and benzopyranone derivatives have the general formula (I) where each of R₁ and R₂ means hydrogen atom, hydroxyl-group, alkoxy-group, respectively; each of R₃-R₇ means hydrogen atom, hydroxyl-group, direct or branched alkyl, alkylhydroxy-group containing 1-6 carbon atoms, halogen atom, amino-group or alkylenedihydroxy-group bound respectively by the point R₃ and R₄, R₄ and R₅, R₅ and R₆ or R₆ and R₇ and A means methylene-group or oxygen atom. Compounds show inhibiting effect on activity of 17-17-hydroxysteroid dehydrogenase and therefore these derivatives can be used for preparing therapeutic agent used for prophylaxis and/or treatment of patients with androgen- and estrogen-dependent diseases, in part, prostate gland cancer, prostate benign hyperplasia, virilism. breast cancer, mastopathy, uterus cancer, ovary cancer and so on. EFFECT: improved method of synthesis, enhanced anticancer activity of compounds. 4 cl, 3 dwg