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1,4-BENZOTHIAZEPINE-1,1-DIOXIDE, PHARMACEUTICAL COMPOSITION DECREASING BLOOD LIPID LEVEL, METHOD OF TREATMENT OF MAMMAL CLINICAL STATE, METHOD OF SYNTHESIS OF COMPOUND
1,4-BENZOTHIAZEPINE-1,1-DIOXIDE, PHARMACEUTICAL COMPOSITION DECREASING BLOOD LIPID LEVEL, METHOD OF TREATMENT OF MAMMAL CLINICAL STATE, METHOD OF SYNTHESIS OF COMPOUND
FIELD: organic chemistry, medicine, pharmacy. SUBSTANCE: invention relates to the novel 1,4-benzodiazepine-1,1-dioxides of the formula (II) where R1, R2 mean direct chain C1-6-alkyl groups; R4 means unsubstituted phenyl; R5, R8 mean hydrogen atom; R6 means methoxy-group or bromine atom; R7a means methoxy-, hydroxy- or trifluoromethyl-group; R9, R10 means hydrogen atom, and to salts, solvates or physiologically functional derivatives, and to method of their synthesis also. Except for, invention describes pharmaceutical composition based on indicated compounds that decreases blood lipid level and method of treatment of mammal clinical state. Invention can be used in medicine, in part, for prophylaxis and treatment of patients with hyperlipidemic states as atherosclerosis. EFFECT: improved method of synthesis, enhanced effectiveness of treatment and prophylaxis. 9 cl, 1 tbl, 53 ex
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机译：领域：有机化学，医学，药学。物质：本发明涉及式（II）的新型1,4-苯并二氮杂-1,1-二氧化物。<图像文件=“ 00000002.GIF” he =“ 28” imgContent =“ undefined” imgFormat =“ GIF” wi = “ 53” />其中R 1 ，R 2 是指直链C 1-6 -烷基; R 4 是指未取代的苯基; R 5 ，R 8 表示氢原子; R 6 表示甲氧基或溴原子; R 7a 表示甲氧基，羟基或三氟甲基。 R 9 ，R 10 是指氢原子，并且对于盐，溶剂化物或生理功能性衍生物以及其合成方法也是如此。除此以外，本发明描述了基于降低血脂水平的所示化合物的药物组合物和治疗哺乳动物临床状态的方法。本发明可以在医学上部分地用于预防和治疗具有高脂血症状态的动脉粥样硬化患者。效果：改进的合成方法，增强的治疗和预防效果。 9厘升，1汤匙，53前
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