AZOLE COMPOUNDS, METHODS OF THEIR SYNTHESIS, ANTIFUNGAL COMPOSITION, METHOD OF COMPOSITION PREPARING, METHOD OF INHIBITION OF DEVELOPMENT AND PROLIFERATION OF FUNGI IN WARM-BLOODED ANIMALS, INTERMEDIATE COMPOUNDS

摘要

FIELD: organic chemistry. SUBSTANCE: invention describes the novel azole compounds of the general formula (I) , its pharmaceutically acceptable salt or base, or stereo-chemically isomeric form where A and B in common form bivalent radical of the formula: -CH=B; D is radical or ; L is radical or ; Alk is C_1-4-alkanediyl; R¹ is halogen atom; R² is hydrogen or halogen atom; R³ is hydrogen atom or phenyl; R⁴ is hydrogen atom or phenyl; R⁵ is hydrogen atom or C_1-6-alkyl; R⁶ is hydrogen atom or C_1-6-alkyl or R⁵ and R⁶ in common with nitrogen atom to which they bound form pyrrolidine or substituted piperazine ring being substituted piperazine ring is substituted at 4-position of piperazine ring with C_1-6-alkyl, hydroxy-C_1-6/ -alkyl. Compounds of the formula (I) are new water-soluble azole antifungal agents of broad spectrum action. Invention describes also method of their synthesis, antifungal composition, method of composition preparing, method of inhibition of development and/or proliferation of fungi in warm-blooded animal and intermediate compounds. EFFECT: new compounds indicated above, improved method of synthesis and preparing, valuable antifungal properties. 11 cl, 6 tbl, 29 ex