CYCLOPEPTIDES, METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION CONTAINING THEREOF, METHOD OF ITS PREPARING

摘要

FIELD: chemistry of peptides, pharmacy. SUBSTANCE: invention relates to the novel cyclopeptides of the formula: cyclo-(nArg-nGly-nAsp-nD-nE) where n, D and E have values given in the invention claim and to pharmaceutical composition based on thereof that showing inhibitory activity with respect to ₃ and/or ₅-integrins and to method of preparing pharmaceutical composition showing inhibitory activity. Cyclopeptides act as inhibitors of integrins and can be used for treatment and prophylaxis of tumors and/or metastasis. EFFECT: new cyclo-peptides indicated above, valuable antitumor properties. 10 cl, 5 ex