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New imidazolylmethyl-biphenyl-sulfonylcyanamides, are sodium-dependent bicarbonate/chloride exchanger inhibitors used e.g. for treating cardiovascular disorders such as cardiac infarction
New imidazolylmethyl-biphenyl-sulfonylcyanamides, are sodium-dependent bicarbonate/chloride exchanger inhibitors used e.g. for treating cardiovascular disorders such as cardiac infarction
Imidazol-1-ylmethyl-biphenyl-sulfonylcyanamides (I) are new. Sulfonylcyanamide compounds of formula (I) and their salts are new. R1 = H, alkyl, -CaH2a-Ph', -CaH2a-Het or -CaH2a-cycloalkyl; a = 0-2; Ph' = phenyl (optionally substituted by 1-3 of halo, CF3, Me, OMe, OH and NR8R9); Het = 1-9C heteroaryl (optionally substituted by 1-3 of halo, CF3, Me, OMe, OH and NR8R9); R8, R9 = H or 1-4C alkyl; R2, R3 = H, halo, CF3, CN, NO2, CH2OR17, COR6, OR7, -O-(2-4C alkylene)-OR17, NR50R51, alkyl, cycloalkyl, -CaH2a-Ph', CaH2a-Het or S(O)aR22; R6 = H, alkyl, OR30 or Ph'; R7 = H, alkyl, Ph' or Het; R22 = alkyl, cycloalkyl or -CaH2a-Ph'; R50, R51 = -(2-4C alkylene)-OR52; R17, R30, R52 = H or alkyl; R4, R5 = H, alkyl, halo, CF3, CN, NO2, S(O)aR16, COR23 or OR24; R16 = alkyl or Ph'; R23 = H, alkyl or OR25; R25 = H or alkyl; R24 = H, alkyl or Ph'; provided that at least one of R2 and R3 = -O-(2-4C alkylene)-OR17 or NR50R51. Unless specified otherwise alkyl moieties have 1-8C and cycloalkyl moieties 3-7C.
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机译：咪唑-1-基甲基-联苯磺酰基氰酰胺（I）是新的。式（I）的磺酰基氰酰胺化合物及其盐是新的。 R1 ＝ H，烷基，-CaH2a-Ph'，-CaH2a-Het或-CaH2a-环烷基; a = 0-2; Ph′＝苯基（任选被1-3个卤素，CF 3，Me，OMe，OH和NR 8 R 9取代）; Het ＝ 1-9C杂芳基（任选地被卤素，CF 3，Me，OMe，OH和NR 8 R 9的1-3取代）; R8，R9 ＝ H或1-4C烷基; R2，R3 = H，卤素，CF3，CN，NO2，CH2OR17，COR6，OR7，-O-（2-4C亚烷基）-OR17，NR50R51，烷基，环烷基，-CaH2a-Ph'，CaH2a-Het或S（ O）aR22; R6 ＝ H，烷基，OR30或Ph′; R7 ＝ H，烷基，Ph′或Het; R22 ＝烷基，环烷基或-CaH2a-Ph'; R50，R51 ＝-（2-4C亚烷基）-OR52; R17，R30，R52 ＝ H或烷基; R4，R5 = H，烷基，卤素，CF3，CN，NO2，S（O）aR16，COR23或OR24; R16 ＝烷基或Ph′; R 23 ＝ H，烷基或OR 25; R 25 ＝ H或烷基; R24 ＝ H，烷基或Ph′;前提是R2和R3中的至少一个＝ -O-（2-4C亚烷基）-OR17或NR50R51。除非另有说明，否则烷基部分具有1-8C且环烷基部分具有3-7C。
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