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New imidazolylmethyl-biphenyl-sulfonylcyanamides, are sodium-dependent bicarbonate/chloride exchanger inhibitors used e.g. for treating cardiovascular disorders such as cardiac infarction
New imidazolylmethyl-biphenyl-sulfonylcyanamides, are sodium-dependent bicarbonate/chloride exchanger inhibitors used e.g. for treating cardiovascular disorders such as cardiac infarction
Imidazol-1-ylmethyl-biphenyl-sulfonylcyanamides (I) are new. Sulfonylcyanamide compounds of formula (I) and their salts are new. R1 = H, alkyl, -CaH2a-Ph', -CaH2a-Het or -CaH2a-cycloalkyl; a = 0-2; Ph' = phenyl (optionally substituted by 1-3 of halo, CF3, Me, OMe, OH and NR8R9); Het = 1-9C heteroaryl (optionally substituted by 1-3 of halo, CF3, Me, OMe, OH and NR8R9); R8, R9 = H or 1-4C alkyl; R2, R3 = H, halo, CF3, CN, NO2, CH2OR17, COR6, OR7, alkyl, cycloalkyl, -CaH2a-Ph', CaH2a-Het or S(O)aR22; R6 = H, alkyl, OR30 or Ph'; R7 = H, alkyl, Het or Ph'; R17, R30 = H or alkyl; R22 = alkyl, cycloalkyl or -CaH2a-Ph'; R4 = S(O)aR16; R16 = alkyl or Ph'. Unless specified otherwise alkyl moieties have 1-8C and cycloalkyl moieties 3-7C.
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机译:咪唑-1-基甲基-联苯磺酰基氰酰胺(I)是新的。式(I)的磺酰基氰酰胺化合物及其盐是新的。 R1 = H,烷基,-CaH2a-Ph',-CaH2a-Het或-CaH2a-环烷基; a = 0-2; Ph′=苯基(任选被1-3个卤素,CF 3,Me,OMe,OH和NR 8 R 9取代); Het = 1-9C杂芳基(任选地被卤素,CF 3,Me,OMe,OH和NR 8 R 9的1-3取代); R8,R9 = H或1-4C烷基; R2,R3 = H,卤素,CF3,CN,NO2,CH2OR17,COR6,OR7,烷基,环烷基,-CaH2a-Ph',CaH2a-Het或S(O)aR22; R6 = H,烷基,OR30或Ph′; R7 = H,烷基,Het或Ph′; R17,R30 = H或烷基; R22 =烷基,环烷基或-CaH2a-Ph'; R4 = S(O)aR16; R 16 =烷基或Ph′。除非另有说明,否则烷基部分具有1-8C且环烷基部分具有3-7C。
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