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Cyanobenzene-boronic acid or ester preparation in high yield comprises treating halo-benzonitrile and trialkyl borate with alkyl lithium, used as intermediate e.g. for liquid crystals, pesticides or drugs
Cyanobenzene-boronic acid or ester preparation in high yield comprises treating halo-benzonitrile and trialkyl borate with alkyl lithium, used as intermediate e.g. for liquid crystals, pesticides or drugs
Preparation of cyanobenzene-boronic acids and esters (I) involves treating a mixture of a halo-benzonitrile (II) and a trialkyl borate (III) with an alkyl lithium (IV) and optionally hydrolyzing the obtained boronic acid ester. Preparation of cyanobenzene-boronic acids and esters of formula (I) involves treating a mixture of a halo-benzonitrile of formula (II) and a trialkyl borate of formula B(OA)3 (III) with an alkyl lithium of formula A-Li (IV) and optionally hydrolyzing the obtained boronic acid ester. R = H or A; R1, R2 = H, A, OA, F, Cl or phenyl (optionally substituted by 1 or 2 of A, OA, F and Cl); A = 1-6C alkyl; L = Br or I.
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机译:氰基苯硼酸和酯的制备(I)涉及用烷基锂(IV)处理卤代苄腈(II)和硼酸三烷基酯(III)的混合物,并任选水解得到的硼酸酯。式(I)的氰基苯硼酸和酯的制备涉及用式A-Li的烷基锂处理式(II)的卤代苄腈和式B(OA)3(III)的硼酸三烷基酯的混合物(IV)和任选地水解所获得的硼酸酯。 R = H或A; R1,R2 = H,A,OA,F,Cl或苯基(任选地被A,OA,F和Cl中的1或2个取代); A = 1-6C烷基; L = Br或I。
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