Oil-in-water emulsion with protective effect against peroxidation damage to human organs, their production and use

摘要

The invention relates to an oil-in-water emulsion comprising, as an active ingredient, alpha -tocopherol or the stereoisomers thereof and comprising, as an emulsifier, phospholipids. The inventive emulsion is used in order to attain a protective action against damages to human organs resulting from peroxidation. The emulsion contains a alpha -tocopherol content, with regard to action, of 1.48 g/l to 30 g/l RRR-g(a)-tocopherol, 0-25 g/l of an oil which is compatible with I.V. administration, and 0.25 g/l to 3 g/l of a phospholipid. The emulsion is preferably administered as an infusion and is especially used to reduce damages resulting from peroxidation due to ischaemia and/or reperfusion and, among other things, during an organ transplantation.