Device for the improved intravascular phonological in with a resolution of intravascular closures and the prevention of restenosis

摘要

Ultrasonic apparatus (10) and method for coupling ultrasonic energy into intravascular walls to enhance phonophoresis and for dissolution of intravascular blockages. The apparatus (10) includes a radiator (44) for coupling ultrasonic waves and a piezoelectric crystal (24), connected with said radiator (44), for the intravascular generation of ultrasonic waves; said ultrasonic waves being propagated along a longitudinal axis (104) of said piezoelectric crystal (24). A seed liquid is introduced proximate the radiator for promoting cavitation of intravascular fluid. In addition, enhancement of dissolution of intravascular blockages and inhibition of restenosis by chemical agents is significantly increased when combined with ultrasonic energy.