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CDNA corresponding to the genome of minus-stranded RNA viruses and method for producing infectious minus-stranded RNA viruses
CDNA corresponding to the genome of minus-stranded RNA viruses and method for producing infectious minus-stranded RNA viruses
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机译:与负链RNA病毒的基因组相对应的cDNA和生产传染性负链RNA病毒的方法
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摘要
The present invention relates, in general, to a methodology for the generation of nonsegmented negative-strand RNA viruses (Pringle, 1991) from cloned deoxyribonucleic acid (cDNA). Such rescued viruses are suitable for use as vaccines, or alternatively, as plasmids in somatic gene therapy applications. The invention also relates to cDNA molecules suitable as tools in this methodology and to helper cell lines allowing the direct rescue of such viruses. Measles virus (MV) is used as a model for other representatives of the Mononegavirales, in particular the family Paramyxoviridae. IMAGE
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