Analogs of the prostaglandin PGE.sub.1 are disclosed. These compounds exhibit uterotonic properties, enhancing the response to PGF. sub.2 . alpha. in isolated rat uteri. The compounds also exhibit other pharmacological properties, as inhibitors of gastric acid secretion, hypotensives, and bronchodilators. Processes for making the analogs, useful intermediates, and pharmaceutical preparations are also presented.
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