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Down-regulation of DNA repair to enhance sensitivity to P53- mediated apoptosis
Down-regulation of DNA repair to enhance sensitivity to P53- mediated apoptosis
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机译:下调DNA修复以增强对P53介导的细胞凋亡的敏感性
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摘要
The present invention details methods for the treatment of cancer. In particular it concerns the induction of apoptosis in cancer cells following treatment with inhibitors of DNA repair in combination with p53. Treatment of glioblastoma and breast tumor cells with inhibitors of DNA repair induced growth suppression that was a result of p53-mediated apoptosis. Thus it appears that inhibitors of DNA repair in combination with p53 is involved in restoration of p53-mediated apoptosis.
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