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Coxsackie virus as a vector for delivery of anti-inflammatory cytokines
Coxsackie virus as a vector for delivery of anti-inflammatory cytokines
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机译:柯萨奇病毒作为传递抗炎细胞因子的载体
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摘要
The present invention is drawn to the use of artificially attenuated Coxsackievirus B3 cardiotropic virus vectors as efficient gene transfer vectors to deliver immunomodulatory proteins and/or antigenic epitopes in transient infections to aid in preventing, ameliorating, and/or ablating infectious viral heart disease and reducing, or ablating entirely, heart transplant rejection. Additionally, other organs or tissues may be targeted with specific picornaviruses. An attenuated CVB3 viral vector able to express a cytokine is provided. This cytokine- expressing viral vector is able to deliver the cytokine to a target tissue and reduce disease symptoms
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