Anti-immunoresponsive polymeric material and its use in biological applications

摘要

A polymer composition comprising an anticoagulant carried in a water soluble polymer hydrogen bonded to a cellulose polymer. The composition is useful as sutures, implantable material, temporary grafts, vasculature connections and the like. The composition can be prepared by a method comprising the steps of: forming a solution in an amine oxide of a water- soluble polymer capable of hydrogen bonding, a cellulose polymer, and an anticoagulant and reducing the amount of amine oxide in the solution to solidify a solid polymer composition comprising the anticoagulant in the water soluble polymer and the cellulose polymer. The polymer compositions are particularly useful in temporary implants, sutures, grafts or the like.