Vanadium complex of monohydroxamic acid salt and pharmaceutical composition comprising the complex

摘要

Monohydroxamate vanadium complexes of the formula (1): R-CO-NHOH.X, wherein R is a residue selected from: (i) H2N-CH(COY)-(CH2)n-, wherein n is 1, 2 or 3, and Y is OH or NH2; (ii) H2N-CH2-S-CH2-; and (iii) pyridyl, piperidyl or tetrahydroisoquinolinyl; and X is a vanadium compound selected from a vanadyl (VO2+), metavanadate (VO3-)or vanadate (VO43-)) salt, are useful for inducing normoglycemia and/or reducing blood glucose levels in diabetic patients.