Inhibitory protein of wnt signaling pathway

摘要

An inhibitory protein (A) of the wnt signaling pathway (which comprises secreted glycoproteins and their associated receptors) that includes at least one of two specified consensus sequences is new. Independent claims are included for: (1) DNA (B) that encodes (A); (2) an expression plasmid containing (B); (3) transformants containing the plasmid of (2); (4) the recombinant production of (A) by culturing the transformants of (3), and (5) antibodies against (A). ACTIVITY : Antitumor. MECHANISM OF ACTION : Inhibition of wnt signaling.