Interaction with neuronal nicotinic acetylcholine receptor and conotoxin peptide - alpha

摘要

(57) while maintaining an active basic MII, [Abstract] The present invention relates to derivatives of (α-4/7 conotoxin peptide) conopeptides amino acids have been substituted as described herein. And the discovery of the three dimensional structure of MII, the invention also relates to a relationship with its specificity for α3β2 subunit neuronal nicotinic acetylcholine receptors and the structure of (nAChR). The invention also relates to a program of computer-based representation for its three-dimensional structure and peptide analogs MI, non-peptide or peptide mimetic. It can then be correlated with biological activity to structural features, to facilitate the design of peptide mimetic indicating the specificity of the same for neuronal nAChR and α-4/7 conotoxin peptide analogs. As cardiovascular agents, and mimetic analog and such are useful in the treatment and detection small cell lung cancer of (SCLC).