Monoclonal antibody recognizing N-glycolylated-galactose-glucose sialic acid oligosaccharide in malignant tumor and composition containing this antibody

摘要

The present invention relates to the branch of immunology and human medicine, in particular to the generation and selection of a monoclonal antibody which recognizes the oligossaccharide N-glycolylated-glucose sialic acid (N-GcNeu-Gal-Glu) present in malignant tumors. One of the objects of this invention is to provide a monoclonal antibody of the IgG1 type which has the characteristic of recognizing with a high specificity the oligosaccharide sequence N-glycolylated-galactose-glucose sialic acid present in malignant mammary tissues as well as in melanomas and tumors of the liver, stomach, colon, rectum and kidney. It also has the capacity of causing direct cytolysis in tumoral cells which carry said oligosaccharide sequences and, as a consequence, can be used for the diagnosis and treatment of certain neoplasic diseases. Another object of the present invention is to provide the hybridome producing said monoclonal antibody, as well as the pharmaceutical composition containing it, for the treatment of neoplasic diseases.