Optical active 3 chloro 2 propanol derivative and its manufacturing method

摘要

PURPOSE:To obtain a new compound useful as a synthetic intermediate for an optically pure medicine, especially a medicine having an optically active 2-propanol structure. CONSTITUTION:The objective compound of the formula (R1 is 2,2-diphenylacetyl, diphenylmethyl or 5-dibenzosuberanyl; * indicates asymmetric carbon), e.g. (2R)-3-chloro-1[4-dibenzosuberan-5-yl)piperazin-1-yl]-2-propanol. This compound of the formula is obtained by subjecting optically active epichlorohydrin and a piperazine derivative to the addition reaction without or in a solvent such as ethanol under cooling conditions with ice or at ambient temperature. Thereby, a 3-chloro-2-propanol derivative having an ultrahigh optical purity can readily be obtained under mild conditions and is then converted into the objective optically active 1-amino-3-alkoxy-2-propanol derivative.