Treatment of mammalian myocardium with topical morphogens or morphogenically treated myogenic precursor cells

摘要

The present invention provides methods for the treatment, and pharmaceuticals for use in the treatment, of mammalian subjects at risk of, or afflicted with, loss of or damage to myocardial tissue. The methods involve the administration of certain morphogens, inducers of those morphogens, agonists of the corresponding morphogen receptors, or small molecule morphogenic activators, or implantation of cells induced with those agents. The morphogens useful in the invention include OP1, CBMP-2A (BMP-2), CBMP-2B (BMP-4), and other members of the morphogens family of the TGF beta superfamily of growth and differentiation factors.