UV LIGHT-MEDIATED SKIN DAMAGE-RELATED GENE AND POLYNUCLEOTIDE, AND THEIR USE

摘要

PROBLEM TO BE SOLVED: To obtain a new polynucleotide expressed in a skin cell, particularly in a keratinized cell and an encoded gene product, and to provide a method using the polynucleotide and encoded gene product.;SOLUTION: Polynucleotides encoding several new protein kinases, which are c-Jun N-terminal kinasekinasekinase, MLK4, PAK4, PAK5, and YSK2 are provided. A method for using the disclosed polynucleotides and their genen products for discovering an agent, particularly for screening an agent capable of reducing the UV light-mediated skin damage, inflammation, and psoriasis is provided, and an agent capable of enhancing the recovery from the injury is also provided.;COPYRIGHT: (C)2001,JPO