HIGH THROUGHPUT HPLC METHOD FOR DETERMINING Log P VALUE

摘要

PROBLEM TO BE SOLVED: To measure a logarithm (log P) of an n-octanol/water distribution coefficient expressing a hydrophobicity of a compound by held data at chromatography. ;SOLUTION: An appropriate HPLC condition is determined so that the log P value of the compound becomes substantially equal to a retention time at an HPLC column. A library of compounds to be evaluated is selected, and log P values of the compounds are determined by the HPLC and stored. The compound having a desired log P value can be easily and quickly selected to carry out a target bioassay.;COPYRIGHT: (C)2001,JPO