dorosupirenon (6 and 7; 7- 15 and -jimechiren - 3 - oxo - -puregun - 4 - en - 21,17 - karuborakuton and DRSP) as a intermediate field for production method and the said method (3 - hydroxy - 1 - propyl) - 6 and 7; 15 and -jimechiren - -ando loss tongue - 3 and -torioru (ZK92836) and 6 and 7; 15 and -jimechiren - -hidorokishi - 3- oxo -17- and loss tongue -21,17- karuborakuton (90965)

摘要

Production of drospirenone (6beta ,7beta ;15beta ,16beta -dimethylene-3-oxo-17alpha -pregn-4-ene-21,17-carbolactone) of formula (I) comprises catalytically hydrogenating 17alpha -(3-hydroxy-1-propynyl)-6beta ,7beta ;15beta ,16beta -dimethylene-5beta -androstane-3beta ,5,17beta -triol of formula (II) to give 17alpha -(3-hydroxypropyl)-6beta ,7beta ;15beta ,16beta -dimethylene-5beta -androstane-3beta ,5,17beta -triol of formula (III), oxidising (III) in the presence of a ruthenium salt to give 6beta ,7beta ;15beta ,16beta -dimethylene-5beta -hydroxy-3-oxo-17alpha -pregnane-21,17-carbolactone of formula (IV), and dehydrating (IV): Also claimed are intermediates (III) and (IV).