PROCESS FOR PREPARING DROSPORENONE (6BETA, 7BETA, 15 BETA, 16BETA-DIMETHYLENE-3-OXO-17ALPHA-PREGN-4-ENE-21,17-CARBOLACTONE, DRSP), AS WELL AS 7ALPHA-(3-HYDROXY-1-PROPYL)-6BETA,7BETA,15BETA,16BETA-DIMETHYLENE-5BETA- -ANDROSTAN-3BETA,5,17BETA-TRIOLE(ZK 92836) AND 6BETA,7BETA,15BETA,16BETA- -DIMETHYLENE-5BETA-HYDROXY-3-OXO-17ALPHA-ANDROSTAN-21,17-CARBOLACTONE (90965) AS INTERMEDIATES OF THIS PROCESS

摘要

In the present invention, there is disclosed a process for preparing drospirenone, 6{beta},7{beta};15{beta},16{beta}-dimethylene-3-oxo-17{alpha} {alpha}-pregn-4-ene-21,17-carbolactone identified as DRSP, by catalytic hydrogenation of 17{alpha}-(3-hydroxy-1-propinyl)-6{beta},7{beta};15{beta},16{beta}-dimethylene-5{beta}-androstane-3{beta},5,17{beta}-triol, identified as ZK 34506, further by oxidizing the obtained 17{alpha}-(3-hydroxy-1-propyl)-6{beta},7{beta};15{beta},16{beta}-dimethylene-5{beta}-androstane-3{beta},5,17{beta}-triol, identified as ZK 92836, in the presence of a ruthenium salt to form 6{beta},7{beta};15{beta},16{beta}-dimethylene-5{beta}-hydroxy-3-oxo-17{alpha}-androstane-21,17-carbolactone, identified as ZK 90965 and dehydrating the latter. Disclosed is also 6{beta},7{beta};15{beta},16{beta}-dimethylene-5{beta}-hydroxy-3-oxo-17{alpha}-androstane-21,17-carbolactone as intermediate used in the above-described preparation process.